Methanol → Methyl 2-(4-benzyloxyphenyl)acetate

Participants

Reaction Conditions

Reaction Steps

Thionyl chloride (60 ml; 0.83 mol) was added drop-wise to a mixture of (4-benzyloxy-phenyl)acetic acid (100 gm; 0.4132 mol) and methanol (300 ml) under constant stirring while maintaining the temperature at 5-10° C. After complete addition, the reaction mixture was stirred for 5-6 hours at room temperature. After completion of the reaction, white crystalline solid was isolated by filtration to yield (4-benzyloxy-phenyl)-acetic acid methyl ester. Yield: 104 g, Efficiency: 98.31%.

Provenance & Evidence