反应详情

A solution of Benzyloxy carbonyl methoxy-acetic acid (40 g) and Thionyl chloride (80 ml) was stirred at reflux temperature for 3 hours. Excess Thionyl chloride was distilled off, to the residue was added toluene (100 ml) and distilled off the solvent completely to get chloro carbonyl methoxy-acetic acid benzyl ester (40 g) as a light brown liquid which was used without further purification.

1. temperatureat reflux temperature for 3 hours
2. distillationExcess Thionyl chloride was distilled off, to the residue
3. additionwas added toluene (100 ml)
4. distillationdistilled off the solvent completely