Water → HCID 68161901, compound

Participants

Reaction Steps

To a solution of 2-Chloro-N-[6-(2-chloro-acetylamino)-hexyl]-acetamide (200 gm) and triethyl amine (400 ml) in Acetone (2000 ml) at room temperature was added dropwise Benzyloxy acetic acid (350 g). The solution was further stirred at reflux temperature overnight. The reaction mixture was poured onto cold water and solids were filtered, dried and the crude product was purified by recrystallisation from Ethyl acetate to yield pure (Benzyloxy-acetic acid-{6-[2-(2-benzyloxy-acetoxy)-acetylamino]-hexylcarbamoyl}-methyl ester) (190 g) as white powder with a melting point of 101-103° C. The product was characterized by 1H NMR (CDCl3+DMSO-d3) δ 1.24 (m, 2H, CH2), 1.43 (m, 2H, CH2), 3.15 (t, 2H, CH2), 4.15 (s, 2H, CH2), 4.48 (s, 2H, CH2), 4.56 (s, 2H, CH2), 7.30 (m, 5H, Ar), 7.46 (t, 1H, NH).

Provenance & Evidence