Methyl Ethyl Ketone → Fesoterodine fumarate

HRID 1473001Notes

Reaction equation

HRID 1473001 reaction equation
[CH3:1][CH:2]([C:4]([O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:29][OH:30])=[CH:11][C:12]=1[C@@H:13]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[CH2:14][CH2:15][N:16]([CH:20]([CH3:22])[CH3:21])[CH:17]([CH3:19])[CH3:18])=[O:5])[CH3:3].[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].CC(=O)CC>C1CCCCC1>[CH3:3][CH:2]([C:4]([O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:29][OH:30])=[CH:11][C:12]=1[C@@H:13]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:14][CH2:15][N:16]([CH:20]([CH3:21])[CH3:22])[CH:17]([CH3:18])[CH3:19])=[O:5])[CH3:1].[CH:32](/[C:31]([OH:38])=[O:37])=[CH:33]\[C:34]([OH:36])=[O:35]

Participants

5

Reactant 3

HCID 6569Methyl Ethyl KetoneHCID 444972Fumaric AcidHCID 6918558Fesoterodine

Product 1

HCID 9849808Fesoterodine fumarate

Reagents, catalysts & solvents 1

HCID 8078CyclohexaneSolvent

Procedure

The fesoterodine of formula (J) is converted into fumarate salt by reacting with fumaric acid in the presence of solvent such as 2-butanone and cyclohexane to obtain pure fesoterodine fumarate.

Sources & evidence

ORD record
ord-8506c00ced2a4451b97c501958a18786
Source dataset
uspto-grants-2015_04
Patent number
US09012678B2

Reaction notes

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