反应详情

To the obtained p-toluyl-L-tartaric acid salt of N,N-Diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropylamine of formula (E) added 500 ml R.O. Water and 300 ml MDC reaction cooled to 0° C. to 5° C. and pH was adjusted at 9 to 10 by 10% sodium hydroxide followed by raising of temperature to 25° C. to 35° C. Layers were separated and MDC layer washed with 2×200 ml 20% brine solution and finally MDC was distilled out under vacuum below 50° C. to afford title compound (R)—N,N-Diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-Phenylpropylamine compound of formula (F).

1. temperaturecooled to 0° C. to 5° C.
2. temperatureby raising of temperature to 25° C. to 35° C
3. customLayers were separated
4. washMDC layer washed with 2×200 ml 20% brine solution and finally MDC
5. distillationwas distilled out under vacuum below 50° C.