Methanol → HCID 15434420, compound

Participants

Reaction Steps

5 gm (R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl propyl)benzoate and 25 ml toluene was added under nitrogen atmosphere to a solution of 5.5 g Vitride in 50 ml toluene at 0° C. to 5° C. After stirring at room temperature for 5 hours, methanol was added drop wise at 0° C. to 5° C. After raising the temperature to room temperature, water and toluene was added and stirred for 30 minutes at 25° C. to 35° C. Layers were separated. Toluene layer after complete distillation afforded the title compound as (R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl propyl)-phenyl]-methanol of formula (H).

Provenance & Evidence