Cyclohexane → Fesoterodine fumarate

Participants

Reaction Steps

A solution of 42 g Fesoterodine of formula (J) in 90 ml methyl ethyl ketone was stirred with 12 g fumaric acid at 80° C. for 1 hour. This was followed by the slow addition of 30 ml cyclohexane under stirring and further stirred for 1 hour at 80° C. The solution was cooled slowly to 25° C. to 30° C. and stirred for 6 hours at the same temperature. The solution was further cooled at 0° C. to 50° C. C and stirred for overnight. The separated solid was filtered and washed with mixture of cyclohexane and methyl ethyl ketone mixture to give fesoterodine fumarate.

Provenance & Evidence