2-Chloromandelic acid → HCID 131732760, compound

Participants

Reaction Steps

Fesoterodine base (5 g) and ethyl acetate (20 ml) were added to a four-neck two liter round bottom flask. Further, 2-chloro-mandelic acid (2.3 g) was added at 25° C. to 35° C. The reaction mass was stirred for 2 hours at 25° C. to 35° C. The reaction mass was cooled to 0° C. to 5° C. The product was filtered and washed with chilled ethyl acetate (2×2.5 ml). The wet cake was dried at 60° C. to 65° C. for 8 to 10 to afford solid fesoterodine 2-chloro-mandelate (Purity by HPLC: 99.8%).

Provenance & Evidence