Diisopropyl Ether → Fesoterodine fumarate

Participants

Reaction Steps

A solution of 42 g Fesoterodine of formula (J) in 240 ml IPA (240 ml) is added at 25° C. to 30° C. and then heated to 50° C. to 55° C. Fumaric acid (17 g) was added to the resulting mass was maintained for 30 minutes and further cooled to 25° C. to 30° C. followed by the addition of diisopropyl ether (840 ml) at 25° C. to 30° C. and maintained for 12 hours. The resulting mass was filtered, washed with diisopropyl ether (2×30 ml) and then dried under vacuum for 24 hours at 45° C. to 50° C. to afford Fesoterodine Fumarate (70 g) (Purity by HPLC: 99.98%).

Provenance & Evidence