HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluoronitrobenzene → HCID 12050748, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Reactant | Carbamic acid, N-[1-(4-aminophenyl)-4-piperidinyl]-, 1,1-dimethylethyl ester | HCID 12050749 | — |
| Product | HCID 12050748 | HCID 12050748 | — |
Reaction Steps
tert-Butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate (G29) can be prepared by nucleophilic aromatic substitution of commercially available tert-butyl piperidin-4-ylcarbamate (G26) and 1-fluoro-4-nitrobenzene (G27) under thermal conditions to give tert-butyl (1-(4-nitrophenyl)piperidin-4-yl)carbamate (G28). Reduction of G28 with hydrogen in the presence of a catalyst, for example 10% palladium on charcoal gives tert-butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate (G29).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012461B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-d86f83cd6ed746b99ee9545d2f9f9325 |
| Source note | uspto-grants-2015_04 |