1-Bromo-2-methylpropane → 2-Tert-butoxy-2-[4-(4-chlorophenyl)-1-isobutyl-6-methyl-7-oxo-pyrrolo[2,3-c]pyridin-5-yl]acetic acid
Reaction equation
[C:1]([O:5][CH:6]([C:11]1[N:16]([CH3:17])[C:15](=[O:18])[C:14]2[NH:19][CH:20]=[CH:21][C:13]=2[C:12]=1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1)[C:7]([O:9]C)=[O:8])([CH3:4])([CH3:3])[CH3:2].Br[CH2:30][CH:31]([CH3:33])[CH3:32]>>[C:1]([O:5][CH:6]([C:11]1[N:16]([CH3:17])[C:15](=[O:18])[C:14]2[N:19]([CH2:30][CH:31]([CH3:33])[CH3:32])[CH:20]=[CH:21][C:13]=2[C:12]=1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1)[C:7]([OH:9])=[O:8])([CH3:3])([CH3:2])[CH3:4]Participants
3
Procedure
The title compound was prepared in a manner similar to that described in Example 2 from methyl 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate and 1-bromo-2-methylpropane. 1H NMR (400 MHz, CHLOROFORM-d) ppm 7.59-7.67 (m, 1H) 7.45-7.51 (m, 2H) 7.39-7.45 (m, 1H) 6.97-7.04 (m, 1H) 5.91-5.98 (m, 1H) 5.30-5.39 (m, 1H) 4.23-4.44 (m, 2H) 3.67 (s, 3H) 2.16-2.31 (m, 1H) 1.01 (s, 9H) 0.88-0.98 (m, 6H); LCMS (m/z) ES+=445 (M+1).
Sources & evidence
- ORD record
- ord-119a360c486c40ac866e2ba74179f057
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09012642B2
Reaction notes
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