4-(Chloromethyl)-2-methyl-1,3-thiazole → HCID 71538482, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 2 from methyl 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate and 4-(chloromethyl)-2-methylthiazole. 1H NMR (400 MHz, CHLOROFORM-d) ppm 7.61-7.74 (m, 1H) 7.33-7.45 (m, 3H) 7.11-7.21 (m, 1H) 7.00-7.08 (m, 1H) 5.93-6.00 (m, 1H) 5.73-5.89 (m, 2H) 3.65 (s, 3H) 2.63 (s, 3H) 0.86 (s, 9H); LCMS (m/z) ES+=500 (M+1).

Provenance & Evidence