HCID 89462644, compound → HCID 89462908, compound

Participants

Reaction Steps

To a solution of 3-(hydroxymethyl)-2-methyl-4-(5-methylchroman-6-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-c]pyridin-1(2H)-one (60 mg, 0.15 mmol) in chloroform (15 mL) was added manganese(IV) oxide (132 mg, 1.5 mmol). The mixture was stirred at reflux for 18 h. After the reaction mixture was cooled to room temperature, the suspension was filtered through a pad of silica gel and the pad was washed with ethyl acetate (20 mL×3). The combined filtrates were concentrated to dryness to give crude title product (50 mg, 84% yield), which was used in the next step directly. LCMS (m/z) ES+=396 (M+1).

Provenance & Evidence