Sodium Bicarbonate → HCID 89463070, compound

Participants

Reaction Steps

To a solution of compound methyl 2-hydroxy-2-(2-methyl-4-(5-methylchroman-6-yl)-1-oxo-1,2,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-c]pyridin-3-yl)acetate (30 mg, 0.066 mmol) in t-Butyl acetate (3 mL) was added HClO4 (6.64 mg, 0.066 mmol). The mixture was stirred at room temperature for 30 min. The reaction mixture neutralized with saturated aqueous NaHCO3 (10 mL). The resulting solution was extracted with ethyl acetate (15 mL×3). The combined ethyl acetate were dried over Na2SO4 and concentrated to dryness to give crude product, which was purification with prep-TLC afford title product (20 mg, 59% yield) as a solid. LCMS (m/z) ES+=510 (M+1)

Provenance & Evidence