2-Chloro-4-(3-nitrophenyl)pyrimidine → 3-(2-Chloropyrimidin-4-yl)aniline

Beteiligte Stoffe

Reaktionsschritte

Intermediate 5 was dissolved in ethanol along with 5 mol % of 5% Pt/C. The mixture was stirred under an atmosphere of H2 for 24 hours and then filtered through a pad of Celite to remove catalyst. Removal of the solvent gave product in 90% yield. LC-MS showed purity>95% and the expected M+H+ of 206.

Herkunft & Nachweise