反应详情

A round bottomed flask was charged with 2,2,2-trifluoroethyl 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate (1.729 g, 4.01 mmol) and CH2Cl2 (8.03 mL). Sodium hydroxide (2M in MeOH) (4.01 mL, 8.03 mmol) was added at rt. The solution was capped and maintained at rt for 18 h resulting in a white precipitate. The white solid was collected by vacuum filtration, rinsing with diethyl ether to yield sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate (1.481 g, 3.99 mmol) as a fluffy white solid. The solid was used directly without further purification.

1. customThe solution was capped
2. customresulting in a white precipitate
3. filtrationThe white solid was collected by vacuum filtration
4. washrinsing with diethyl ether