Dimethylformamide → HCID 86687364, compound

Participants

Reaction Steps

To a solution of 5-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)naphthalene-2-sulfonic acid (from Step 2) (0.093 g, 0.214 mmol) in DMF (0.428 mL) was added thionyl chloride (0.031 mL, 0.428 mmol) at 0° C. After 20 minutes LC/MS indicated that the sulfonic acid starting material was converted to the desired product. The reaction mixture was then transferred to a separatory funnel containing water and DCM. The layers were separated and the organic layer was washed twice with water. The resulting organic layer was dried with MgSO4, filtered and concentrated to an oil. m/z (ESI, +ve ion) 450.9 (M+1).

Provenance & Evidence