2-Aminothiazole → 5-(2-chloro-4-(trifluoromethyl)phenyl)-N-(oxazol-2-yl)naphthalene-2-sulfonamide

Participants

Reaction Steps

This product was prepared as described in EXAMPLE 41, using perfluorophenyl 5-(2-chloro-4-(trifluoromethyl)phenyl)naphthalene-2-sulfonate and oxazole-2-amine instead of perfluorophenyl 5-bromonaphthalene-2-sulfonate and thiazole-2-amine. The residue was taken up in minimal CH2Cl2 and absorbed onto a 5 g loading cartridge and passed through a silica gel column (12 g) using a gradient from 5% to 100% EtOAc to Heptanes and then triturated with an IPA/DCM/Heptanes mixture to give desired product 5-(2-chloro-4-(trifluoromethyl)phenyl)-N-(oxazol-2-yl)naphthalene-2-sulfonamide (0.010 g, 0.022 mmol) as an off-white solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 6.88 (d, J=1.76 Hz, 2H) 7.09 (d, J=1.76 Hz, 1H) 7.45-7.60 (m, 3H) 7.62-7.78 (m, 2H) 7.82-7.96 (m, 2H) 8.08 (d, J=8.61 Hz, 1H) 8.60 (d, J=1.76 Hz, 1H); m/z (ESI, +ve ion) 453.0 (M+H)+.

Provenance & Evidence