HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-amine → 5-(2-Chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-YL)naphthalene-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-amine | HCID 578640 | — |
| Reactant | 5-bromo-N-(pyrimidin-4-yl)naphthalene-2-sulfonamide | HCID 86687367 | — |
| Reactant | Perfluorophenyl 5-(2-chloro-4-(trifluoromethyl)phenyl)naphthalene-2-sulfonate | HCID 86687371 | — |
| Product | 5-(2-Chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-YL)naphthalene-2-sulfonamide | HCID 86687387 | — |
Reaction Steps
The title compound was prepared in an analogous manner to that of intermediate W, except that N-(4-methoxybenzyl)thiazol-2-amine was used in place of 4-aminopyrimidine and perfluorophenyl 5-(2-chloro-4-(trifluoromethyl)phenyl)naphthalene-2-sulfonate (intermediate Z) was used instead of perfluorophenyl 5-bromonaphthalene-2-sulfonate. MS (ESI, positive) m/z: 588.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012443B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-10f6f97848464e7e9e8f47ec860c6c7b |
| Source note | uspto-grants-2015_04 |