Hydrochloric Acid → 1-Benzhydryl-3-hydrazinylazetidine hydrochloride

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared as described in WO2010079443A1. To a mixture of tert-butyl 2-(1-benzhydrylazetidin-3-yl)hydrazinecarboxylate (16 g) and 4 N HCl in dioxane (10 mL/1 g) was stirred at 25° C. for 3 h. The solvent was completely evaporated off to obtain a crude product. The crude product was washed with diethyl ether to obtain a white solid, 1-benzhydryl-3-hydrazinylazetidine hydrochloride (15.5 g). This was used as is for the next step.

Provenance & Evidence