反应详情

1-(4-fluoro-2-hydroxyphenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)isoquinoline-6-sulfonamide was dissolved in DCM (1 ml) and TFA (1 ml) and stirred at ambient temperature for 2 h. The mixture was purified by reverse phase chromatography, eluting with 0.1% NH4OH in ACN and water as mobile phase to obtain 1-(4-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)isoquinoline-6-sulfonamide (20 mg, 22%). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.88 (br. s., 1H) 10.19 (s, 1H) 8.65 (d, J=5.67 Hz, 1H) 8.51 (d, J=1.56 Hz, 1H) 8.06 (d, J=5.87 Hz, 1H) 7.78-7.91 (m, 2H) 7.34 (t, J=7.78 Hz, 1H) 7.26 (d, J=4.50 Hz, 1H) 6.76-6.88 (m, 3H). m/z (ESI) 402.0 (M+H)+.

1. customThe mixture was purified by reverse phase chromatography
2. washeluting with 0.1% NH4OH in ACN and water as mobile phase