(2-Methoxy-4-(trifluoromethyl)phenyl)boronic acid → HCID 86687515, compound

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The title compound was prepared in an analogous manner to that of Example 228, except that 1-chloro-4-cyano-N-(4-methoxybenzyl)-N-(pyrimidin-4-yl)isoquinoline-6-sulfonamide and (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid were used as the coupling partners. The final compound was purified via column chromatography (12 g silica gel column, gradient elution 50 to 100% EtOAc:Heptane) to afford 4-cyano-1-(2-methoxy-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)isoquinoline-6-sulfonamide as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm=9.30 (s, 1H), 8.68-8.51 (m, 2H), 8.14 (d, J=9.6 Hz, 1H), 7.91 (d, J=8.7 Hz, 1H), 7.67-7.60 (m, 1H), 7.59-7.49 (m, 2H), 3.76 (s, 3H). m/z (ESI) 486.2 (M+H)+.

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