Acetic Acid → HCID 86687519, compound

Participants

Reaction Steps

Perfluorophenyl 1-(pyrrolidin-2-yl)isoquinoline-6-sulfonate 2,2,2-trifluoroacetate (Intermediate ZZZ; 0.100 g, 0.179 mmol) and tetrahydro-4h-pyran-4-one (0.025 ml, 0.269 mmol) were dissolved in DCM (1.791 ml). Sodium triacetoxyborohydride (0.114 g, 0.537 mmol) and acetic acid (0.015 ml, 0.269 mmol) were added and the reaction was stirred for one hour at room temperature. Water was added followed by ethyl acetate. The aqueous layer was extracted with ethyl acetate, and the combined organic layers were washed with brine, dried with sodium sulfate, filtered, and concentrated to afford perfluorophenyl 1-(1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-2-yl)isoquinoline-6-sulfonate as an oily blue solid. m/z (ESI) 529.3 (M+H)+.

Provenance & Evidence