Trifluoroacetic acid → HCID 86687557, compound

Participants

Reaction Steps

1-(2-Methoxy-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-4-oxo-N-(thiazol-2-yl)-3,4-dihydrophthalazine-6-sulfonamide (40 mg, 0.066 mmol) was dissolved in DCM (664 μl) and then TFA (25.6 μl, 0.332 mmol) was added at RT. After stirring for 30 min, the reaction was quenched with saturated aqueous NaHCO3 (1 mL). A white solid precipitated out of the solution and was filtered off with the aid of water. The solid was washed with 3 mL of water and dried to afford the product 1-(2-methoxy-4-(trifluoromethyl)phenyl)-4-oxo-N-(thiazol-2-yl)-3,4-dihydrophthalazine-6-sulfonamide (16 mg, 50% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm 3.78 (s, 3H), 6.83 (d, J=4.38 Hz, 1H), 7.24 (d, J=4.49 Hz, 1H), 7.41-7.53 (m, 3H), 7.60 (d, J=7.80 Hz, 1H), 8.15 (dd, J=8.49, 1.87 Hz, 1H), 8.63 (d, J=1.82 Hz, 1H), 13.10 (s, 1H). m/z (ESI) 483.0 (M+H)+.

Provenance & Evidence