2-Aminothiazole → HCID 86687570, compound

Participants

Reaction Conditions

Reaction Steps

A flask containing a solution of 2-aminothiazole (0.039 g, 0.386 mmol) and perfluorophenyl 4-chloro-6-fluoroquinoline-7-sulfonate (0.150 g, 0.351 mmol) in THF (1.754 ml) was cooled to −78° C. for 10 minutes, and then lithium bis(trimethylsilyl)amide, 1.0 m solution in tetrahydrofuran (0.701 ml, 0.701 mmol) was added drop wise (conversion from colorless solution to yellow-orange). After 20 minutes, the reaction was diluted with sat. aq ammonium chloride solution, and was extracted with DCM:MeOH (90:10) (×3). The organics were dried over sodium sulfate, filtered and concentrated in vacuo. The material was taken forward crude. m/z (ESI) 344.0 (M+H)+.

Provenance & Evidence