Trifluoroacetic acid → HCID 86687578, compound

Participants

Reaction Steps

A solution of 3-bromo-N-(4-methoxybenzyl)-4-(2-methoxyphenyl)-N-(thiazol-2-yl)quinoline-7-sulfonamide (from STEP 1 of EXAMPLE 324, 15 mg, 0.025 mmol) in DCM (1 mL) was treated with TFA (0.5 mL). After 30 min, the mixture was diluted with MeOH, and then concentrated in vacuo. The residue was purified by chromatography on silica gel (12-g Redi-Sep Gold column, 0-5% MeOH/DCM) to give 3-bromo-4-(2-methoxyphenyl)-N-(thiazol-2-yl)quinoline-7-sulfonamide (11.8 mg, 0.025 mmol, 99% yield) as a light-yellow solid. 1H NMR (400 MHz, DMSO-d6) δ=13.12 (br. s., 1H), 9.06 (d, J=4.4 Hz, 1H), 8.44 (d, J=1.8 Hz, 1H), 7.85 (dd, J=1.9, 8.9 Hz, 1H), 7.69 (s, 1H), 7.62-7.48 (m, 3H), 7.34-7.22 (m, 2H), 7.14 (dt, J=0.7, 7.4 Hz, 1H), 3.67 (s, 3H). m/z (ESI) 476.2 (M+H)+.

Provenance & Evidence