(4-Fluoro-2-methoxyphenyl)boronic acid → 4-fluoro-1-(4-fluoro-2-methoxyphenyl)-N-(1,2,4-thiadiazol-5-yl)isoquinoline-6-sulfonamide

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The title compound was prepared in an analogous manner to that of EXAMPLE 228, except that 1-chloro-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(1,2,4-thiadiazol-5-yl)isoquinoline-6-sulfonamide and (4-fluoro-2-methoxyphenyl)boronic acid were used as the coupling partners. The final compound was purified via column chromatography (RediSep Gold 12 g silica gel column, gradient elution 0-10% MeOH:DCM) to afford 4-fluoro-1-(4-fluoro-2-methoxyphenyl)-N-(1,2,4-thiadiazol-5-yl)isoquinoline-6-sulfonamide as an off-white solid. 1H NMR (400 MHz, DMSO-d6) δ=8.72 (d, J=1.5 Hz, 1H), 8.49 (s, 2H), 8.00 (dd, J=1.7, 8.9 Hz, 1H), 7.86-7.78 (m, 1H), 7.38 (dd, J=6.9, 8.3 Hz, 1H), 7.16 (dd, J=2.3, 11.4 Hz, 1H), 6.97 (dt, J=2.3, 8.4 Hz, 1H), 3.67 (s, 3H). m/z (ESI) 435.2 (M+H)+.

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