Trifluoroacetic acid → HCID 86687672, compound

Participants

Reaction Steps

1-(2-(cyanomethoxy)phenyl)-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)isoquinoline-6-sulfonamide (0.084 g, 0.141 mmol) was dissolved in DCM and TFA (0.1 mL, 1.298 mmol) was added. The reaction was stirred for 30 minutes at room temperature. The reaction was concentrated and purified via column chromatography (RediSep Gold 12 g, gradient elution 0-10% MeOH:DCM) to afford 1-(2-(cyanomethoxy)phenyl)-4-fluoro-N-(thiazol-2-yl)isoquinoline-6-sulfonamide as a tan solid. 1H NMR (400 MHz, DMSO-d6) δ=13.00 (br. s., 1H), 8.74 (d, J=1.6 Hz, 1H), 8.51 (d, J=1.6 Hz, 1H), 7.98 (dd, J=1.7, 8.9 Hz, 1H), 7.77 (d, J=8.8 Hz, 1H), 7.69-7.59 (m, 1H), 7.48-7.36 (m, 2H), 7.34-7.22 (m, 2H), 6.89 (d, J=4.4 Hz, 1H), 5.09 (s, 2H). m/z (ESI) 441.0 (M+H)+.

Provenance & Evidence