1,4-Dioxane → 1-(4'-fluoro-3,3'-dimethoxy-[1,1'-biphenyl]-4-yl)-N-(pyrimidin-4-yl)isoquinoline-6-sulfonamide

Participants

Reaction Conditions

Reaction Steps

A microwave vial charged with PdCl2(Amphos)2 (0.025 g, 0.035 mmol), 4-fluoro-3-methoxyphenylboronic acid (0.119 g, 0.703 mmol), 1-(4-chloro-2-methoxyphenyl)-N-(pyrimidin-4-yl)isoquinoline-6-sulfonamide (0.150 g, 0.351 mmol), potassium phosphate (0.298 g, 1.406 mmol), 1.5 mL dioxane, and 0.5 mL water was heated to 150° C. in the microwave for 40 minutes. LC/MS showed product, so the aqueous layer was removed. The reaction mixture was treated with excess HCl (4N in dioxane) and was allowed to stir for 10 minutes. The reaction mixture was then concentrated. Purification of the crude residue by reverse phase column chromatography [Puriflash C18, 10-100% (0.1% NH4OH in MeOH)/(0.1% NH4OH in water)] gave 1-(4′-fluoro-3,3′-dimethoxy-[1,1′-biphenyl]-4-yl)-N-(pyrimidin-4-yl)isoquinoline-6-sulfonamide (0.030 g, 0.058 mmol, 16.5%). 1H NMR (MeCN-d3) δ: 8.69 (d, J=5.7 Hz, 1H), 8.62 (s, 1H), 8.48 (s, 1H), 8.20 (d, J=6.4 Hz, 1H), 7.89-7.98 (m, 2H), 7.80 (d, J=9.0 Hz, 1H), 7.34-7.47 (m, 4H), 7.19-7.33 (m, 2H), 7.06 (d, J=6.3 Hz, 1H), 3.98 (s, 3H), 3.71-3.75 (m, 3H) (M+H)+=517.1.

Provenance & Evidence