Dichloromethane → HCID 86687724, compound

Participants

Reaction Steps

In a vial, 1-(5-chloro-2-methoxyphenyl)-N-(4-methoxybenzyl)-4-oxo-N-(thiazol-2-yl)-3,4-dihydrophthalazine-6-sulfonamide (56 mg, 0.098 mmol) was dissolved in DCM (984 μl, 0.098 mmol) and then TFA (37.9 μl, 0.492 mmol) was added. After 30 min at rt, LCMS showed product. The reaction was quenched with saturated aqueous NaHCO3 (1 mL). White solid precipitated out of the solution and was filtered off with the aid of water. The solid was washed with 3 mL of water and dried to afford 1-(5-chloro-2-methoxyphenyl)-4-oxo-N-(thiazol-2-yl)-3,4-dihydrophthalazine-6-sulfonamide (32 mg, 72.4% yield). m/z (ESI) 449.0 (M+H)+.

Provenance & Evidence