1-Bromo-4-iodo-2-methoxybenzene → HCID 86687758, compound

Participants

Reaction Steps

A solution of 1-bromo-4-iodo-2-methoxybenzene (Combi-Blocks, 3.00 g, 9.59 mmol) in 40 mL ether was cooled to −78° C. and was treated with n-butyllithium (4.22 ml, 10.55 mmol). After stirring for 10 minutes, the reaction mixture was quenched with 3-oxetanone (0.967 ml, 13.42 mmol), and the cooling bath was removed. After stirring for an additional hour, LC/MS showed mostly product, so the reaction mixture was washed with 1N citric acid solution, the organics dried over MgSO4 and concentrated. This material was carried on to step two without purification. (M+H)+=240.9.

Provenance & Evidence