Water → HCID 86687762, compound

Participants

Reaction Steps

A solution of 4-(7-(benzylthio)-2-methylquinazolin-4-yl)-3-methoxybenzonitrile (0.371 g, 0.933 mmol) in 8 mL DCM and 0.2 mL (3:2 HOAc/water) solution was cooled to 0° C. and was treated with 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione (0.368 g, 1.867 mmol). After stirring for 15 minutes, LC/MS showed mostly product, so the reaction mixture was diluted with water. The layers were separated, and the organics were dried over MgSO4 and concentrated. Purification of the crude residue by silica gel column chromatography (0-50% EtOAc/heptane) gave 4-(4-cyano-2-methoxyphenyl)-2-methylquinazoline-7-sulfonyl chloride (0.214 g, 0.572 mmol, 61.3% yield). (M+H)+=374.1.

Provenance & Evidence