4,5-Dihydro-2-thiazolamine → HCID 86687764, compound

HRID 1473681Notes

Reaction equation

HRID 1473681 reaction equation
[S:1]1[CH2:5][CH2:4][N:3]=[C:2]1[NH2:6].[CH3:7][O:8][C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=1[C:19]1[C:28]2[C:23](=[CH:24][C:25]([S:29](Cl)(=[O:31])=[O:30])=[CH:26][CH:27]=2)[N:22]=[CH:21][N:20]=1>>[S:1]1[CH2:5][CH2:4][N:3]=[C:2]1[NH:6][S:29]([C:25]1[CH:24]=[C:23]2[C:28]([C:19]([C:10]3[CH:11]=[CH:12][C:13]([C:15]([F:18])([F:16])[F:17])=[CH:14][C:9]=3[O:8][CH3:7])=[N:20][CH:21]=[N:22]2)=[CH:27][CH:26]=1)(=[O:31])=[O:30]

Participants

3

Reactant 2

HCID 156894,5-Dihydro-2-thiazolamineHCID 86687533HCID 86687533, compound

Product 1

HCID 86687764HCID 86687764, compound

Procedure

The title compound was prepared in a manner analogous to example 512 except 4,5-dihydrothiazol-2-amine (Pfaltz & Bauer) was used instead of 2-aminothiazole and 4-(2-methoxy-4-(trifluoromethyl)phenyl)quinazoline-7-sulfonyl chloride was used instead of 4-(4-(difluoromethyl)-5-fluoro-2-methoxyphenyl)quinazoline-7-sulfonyl chloride. (M+H)+=469.0.

Sources & evidence

ORD record
ord-e14cdfce9d694dc3bc146779cf419c91
Source dataset
uspto-grants-2015_04
Patent number
US09012443B2

Reaction notes

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