反应详情

A mixture of 6-tert-Butyl 1-ethyl (E)-(S)-5-[(tert-butoxycarbonyl)amino]-2-(3-fluoropropyl)hex-2-enedioate and 6-tert-Butyl 1-ethyl (Z)—(S)-5-[(tert-butoxycarbonyl)amino]-2-(3-fluoro-propyl)hex-2-enedioate (100 mg, 0.25 mmol) and palladium (20.0 mg, 10% on charcoal, 0.02 mmol) in ethanol (10 mL) were stirred for 2 h at r.t. under a hydrogen atmosphere. Then the mixture was filtered through Celite® and concentrated under reduced pressure. The crude product was purified by column chromatography (silica, hexanes/ethyl acetate gradient).

1. filtrationThen the mixture was filtered through Celite®
2. concentrationconcentrated under reduced pressure
3. customThe crude product was purified by column chromatography (silica, hexanes/ethyl acetate gradient)