Sodium Chloride → Mometasone

HRID 1473731Notes

Reaction equation

HRID 1473731 reaction equation
[CH3:1][C@H:2]1[C@:19]([O:24]C(C2OC=CC=2)=O)([C:20]([CH2:22][Cl:23])=[O:21])[C@:18]2([CH3:32])[C@H:4]([C@H:5]3[C@:15]([Cl:34])([C@@H:16]([OH:33])[CH2:17]2)[C@:14]2([CH3:35])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[CH2:7][CH2:6]3)[CH2:3]1.[Na+].[Cl-]>O>[CH3:1][C@H:2]1[C@:19]([OH:24])([C:20]([CH2:22][Cl:23])=[O:21])[C@:18]2([CH3:32])[C@H:4]([C@H:5]3[C@:15]([Cl:34])([C@@H:16]([OH:33])[CH2:17]2)[C@:14]2([CH3:35])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[CH2:7][CH2:6]3)[CH2:3]1

Participants

4

Reactant 2

HCID 5234Sodium ChlorideHCID 441336Mometasone furoate

Product 1

HCID 441335Mometasone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A sample of the complexed mometasone furoate monohydrate stock suspension (4 g) was mixed with an appropriate diluent (27.2 g) (deionized water or saline (0.9% NaCl/deionized water (w/w)) and mixed thoroughly to obtain the 0.05% w/w mometasone formulations containing 0.097% HPMC, 0.002% sodium lauryl sulfate, 0.014% methylparaben sodium, 0.016% citric acid anhydrous, 0.009% potassium sorbate and approximately 0.5 ppm of 30% simethicone emulsion.

Workup

  1. additionmixed thoroughly

Sources & evidence

ORD record
ord-30bda107671b4334b8df981f6c61ac83
Source dataset
uspto-grants-2015_04
Patent number
US09017728B2

Reaction notes

Loading…