2-Phenylvinyl acetate → Hydroxystyrene amyloxystyrene
Reaction equation
C([O:4][CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=O)C.[CH2:13]([O:18][CH:19]=[CH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:14][CH2:15][CH2:16][CH3:17]>>[OH:4][CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH2:13]([O:18][CH:19]=[CH:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH2:14][CH2:15][CH2:16][CH3:17]Participants
Procedure
The polymer used herein may be synthesized by any desired methods, for example, by dissolving acetoxystyrene and amyloxystyrene monomers in an organic solvent, adding a radical initiator thereto, effecting heat polymerization, and subjecting the resulting polymer to alkaline hydrolysis in the organic solvent to deprotect the acetoxy group, thereby obtaining a hydroxystyrene-amyloxystyrene copolymer. Examples of the organic solvent which can be used for polymerization include toluene, benzene, tetrahydrofuran, diethyl ether and dioxane. Examples of the polymerization initiator used herein include 2,2′-azobisisobutyronitrile (AIBN), 2,2′-azobis(2,4-dimethylvaleronitrile), dimethyl 2,2-azobis(2-methylpropionate), benzoyl peroxide, and lauroyl peroxide. Preferably the system is heated at 50 to 80° C. for polymerization to take place. The reaction time is 2 to 100 hours, preferably 5 to 20 hours. For the alkaline hydrolysis, aqueous ammonia, triethylamine or the like may be used as the base. The reaction temperature is −20° C. to 100° C., preferably 0° C. to 60° C., and the reaction time is 0.2 to 100 hours, preferably 0.5 to 20 hours.
Workup
- customThe polymer used herein may be synthesized by any desired methods
- additionadding a radical initiator
- temperatureeffecting heat
- custompolymerization
- customhydrolysis in the organic solvent
Sources & evidence
- ORD record
- ord-6df40590675844a296ac792ac11c408b
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09017905B2
Reaction notes
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