反应详情

温度

0 °C

To a solution of 4-ethoxyamino-1-methoxy-piperidine-4-carbonitrile (2.0 g, 10.04 mmol), triethylamine (3.49 ml, 2.54 g, 25.09 mmol) and a catalytic amount of 4-dimethylamino-pyridine in tetrahydrofuran (10 ml) at 0° C. was added a solution of (4-chloro-2,6-dimethyl-phenyl)-acetyl chloride (2.18 g, 10.04 mmol) in tetrahydrofuran (1 ml) dropwise. The suspension was stirred at 0° C. for 15 minutes, and at room temperature overnight. The reaction mixture was evaporated, diluted with ethyl acetate and water, and the layers separated. The aqueous phase was extracted with ethyl acetate, the combined organic layers washed with brine, dried over sodium sulfate and concentrated. The crude material was triturated with diisopropyl ether, filtered and the filtrate concentrated. The oily residue was purified by chromatography on silica gel (ethyl acetate/hexane 1:1). Yield: 1.53 g of 2-(4-chloro-2,6-dimethyl-phenyl)-N-(4-cyano-1-methoxy-piperidin-4-yl)-N-ethoxy-acetamide (title compound P3ii.49) as a colorless oil, which solidified upon standing, mp 100-103° C.

1. customat room temperature
2. customovernight
3. customThe reaction mixture was evaporated
4. additiondiluted with ethyl acetate and water
5. customthe layers separated
6. extractionThe aqueous phase was extracted with ethyl acetate
7. washthe combined organic layers washed with brine
8. dry with materialdried over sodium sulfate
9. concentrationconcentrated
10. customThe crude material was triturated with diisopropyl ether
11. filtrationfiltered
12. concentrationthe filtrate concentrated
13. customThe oily residue was purified by chromatography on silica gel (ethyl acetate/hexane 1:1)