Dimethylformamide → 2,5-Dithien-2-ylterephthalic acid chloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,5-dithien-2-ylterephthalic acid (4.06 g, 12.29 mmol) and oxalyl chloride (3.12 g, 24.58 mmol) in DCM (100 cm3) is added DMF (1 cm3) at 0° C. After 10 minutes, this mixture is allowed to warm to 23° C. and stirred overnight. The solvent is removed under reduced pressure to give the crude product as a yellow oil (4.38 g, 97%). 1H NMR (300 MHz, CDCl3): δ(ppm) 7.90 (s, 2H, Ar—H), 7.51 (dd, J=4.9 and 1.4 Hz, 2H, Ar—H), 7.13-7.20 (m, 4H, Ar—H). This product is used for next step without further purification.

Provenance & Evidence