Hydrochloric Acid → HCID 71522974, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methyl 2,6-difluoro-4-(2-{(1S,2R)-2-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]cyclopropyl}ethoxy)benzoate (16.0 mg, 0.038 mmol) in MeOH (0.75 mL) was treated with NaOH aqueous solution (0.076 mL, 5 M, 0.38 mmol). It was heated at 60° C. for 4 hours. The mixture was cooled to RT, acidified with 2N HCl, diluted with EtOAc, washed with water, brine, dried with sodium sulfate. The solvent was removed under reduced pressure to yield Example 2. LCMS calc: 407.37; obs: 408.01 (M+1).

Provenance & Evidence