反应详情

温度

40 °C

A 500 ml round bottom flask was charged with epibromohydrin (5.8 g, 42 mmol), linoleyl alcohol (15 g, 56 mmol), a stir bar, and then flushed with nitrogen. Anhydrous DCM (250 ml) was added via cannula, followed by BF3.Et2O (0.53 ml, 4.2 mmol), and stirred at 40° C. for 3 hours. Progress of reaction was monitored by TLC to ensure no epoxide was remaining. The reaction mixture was transferred to a 500 ml separatory funnel with DCM (2×50 ml), washed with NaHCO3 (2×200 ml), water (200 ml), brine (200 ml), dried with MgSO4, and solvent evaporated. The crude product was purified using column chromatography on silica gel (300 g) with 5-15% ether gradient in hexanes to yield 12.6 g.

1. customflushed with nitrogen
2. additionAnhydrous DCM (250 ml) was added via cannula
3. customProgress of reaction
4. washwashed with NaHCO3 (2×200 ml), water (200 ml), brine (200 ml)
5. dry with materialdried with MgSO4, and solvent
6. customevaporated
7. customThe crude product was purified
8. customto yield 12.6 g