Ethyl trifluoroacetate → HCID 178506277, compound

Participants

Reaction Steps

To a solution of hydrazine hydrate (2.7 mL, 48.6 mmol) in EtOH (80 mL) was added ethyl 2,2,2-trifluoroacetate (6.3 mL, 48.6 mmol). The reaction was aged at room temperature for 90 minutes and concentrated in vacuo. To the crude residue was added EtOH (50 mL) and formamidine acetate (5.1 g, 48.6 mmol) and the reaction was warmed to reflux for 3 h. The reaction was cooled, concentrated in vacuo, and taken up in EtOAc and washed with sat. aq. NaHCO3 (2×). The organic layer was dried (MgSO4) and concentrated to give a pale yellow oil which was used without further purification. 1H NMR (CDCl3, 400 MHz) δ 13.6 (br s, 1H), 8.5 (s, 1H).

Provenance & Evidence