Morpholine → 3-Bromo-5-morpholinobenzonitrile

HRID 1473858Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8](F)[CH:9]=1)[C:5]#[N:6].[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:9]=1)[C:5]#[N:6]

Participants

Reactant 2

HCID 8083Morpholine

HCID 27833303-Bromo-5-fluorobenzonitrile

Product 1

HCID 446273673-Bromo-5-morpholinobenzonitrileYield 81%

Procedure

3-bromo-5-morpholinobenzonitrile was prepared according procedure M from 3-bromo-5-fluorobenzonitrile and morpholine in 81% yield.

Sources & evidence

ORD record: ord-ce79b78240474121a2822db2d5d16441
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09018205B2

Reaction notes

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