HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloropyrimidine → 3-(2-Chloropyrimidin-4-yl)-5-morpholinobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Reactant | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reactant | 3-Bromo-5-morpholinobenzonitrile | HCID 44627367 | — |
| Reactant | 3-Morpholino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile | HCID 44627474 | — |
| Product | 3-(2-Chloropyrimidin-4-yl)-5-morpholinobenzonitrile | HCID 44627480 | — |
Reaction Steps
3-(2-Chloropyrimidin-4-yl)-5-morpholinobenzonitrile was prepared according procedure B from 2,4-dichloropyrimidine and 3-morpholino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile which was synthesized by following procedure A using 3-bromo-5-morpholinobenzonitrile and bis(pinacolato)diboron.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018205B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-82a73f4b2114413a8e8eda0138c7958b |
| Source note | uspto-grants-2015_04 |