3-(2-Chloropyrimidin-4-yl)-5-morpholinobenzonitrile → HCID 25221251, compound

HRID 1473868Notes

Reaction equation

HRID 1473868 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[C:14]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[CH:15]=2)[C:11]#[N:12])[CH:5]=[CH:4][N:3]=1.[CH3:22][O:23][CH:24]1[CH2:29][CH2:28][N:27]([C:30]2[N:34]=[CH:33][N:32]([C:35]3[CH:41]=[CH:40][C:38]([NH2:39])=[CH:37][CH:36]=3)[N:31]=2)[CH2:26][CH2:25]1>>[CH3:22][O:23][CH:24]1[CH2:29][CH2:28][N:27]([C:30]2[N:34]=[CH:33][N:32]([C:35]3[CH:41]=[CH:40][C:38]([NH:39][C:2]4[N:7]=[C:6]([C:8]5[CH:9]=[C:10]([CH:13]=[C:14]([N:16]6[CH2:21][CH2:20][O:19][CH2:18][CH2:17]6)[CH:15]=5)[C:11]#[N:12])[CH:5]=[CH:4][N:3]=4)=[CH:37][CH:36]=3)[N:31]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 446274803-(2-Chloropyrimidin-4-yl)-5-morpholinobenzonitrileHCID 68771341HCID 68771341, compound

Product 1

HCID 25221251HCID 25221251, compound

Procedure

3-(2-(4-(3-(4-methoxypiperidin-1-yl)-1H-1,2,4-triazol-1-yl)phenylamino)pyrimidin-4-yl-5-morpholinobenzonitrile was obtained by following procedure E using 3-(2-chloropyrimidin-4-yl)-5-morpholinobenzonitrile and 4-(3-(4-methoxypiperidin-1-yl)-1H-1,2,4-triazol-1-yl)aniline. MS (ESI) 538.23 (M+H).

Sources & evidence

ORD record
ord-4a8f3747ba384b56bd3d1fa2b50cbd7a
Source dataset
uspto-grants-2015_04
Patent number
US09018205B2

Reaction notes

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