HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-(Imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxybenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Hydroxy-2-Methoxybenzaldehyde | HCID 358341 | — |
| Reactant | 8-(Chloromethyl)imidazo[1,2-a]pyridine | HCID 21661582 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(Imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxybenzaldehyde | HCID 89656580 | — |
Reaction Conditions
| Temperature | 125 °C |
|---|
Reaction Steps
A mixture of 5-hydroxy-2-methoxybenzaldehyde (723.6 mg, 4.7 mmol), 8-(chloromethyl)-imidazol[1,2-a]pyridine (785 mg, 4.7 mmol), and K2CO3 (1.9 g, 14.1 mmol) in DMF (20 mL) was heated at microwave reactor at 125° C. for 15 min. The mixture was filtered and concentrated. The residue was purified on silica gel (50-100% EtOAc in hexanes) to give 5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxybenzaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018210B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-0e8a0949e989490bae550f01d66a4061 |
| Source note | uspto-grants-2015_04 |