Pyridine → 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(methylcarbamoylmethoxyamino-methyl)-benzamide

HRID 147392Notes

Reaction equation

HRID 147392 reaction equation
[BH3:39].[CH2:46]([Cl:47])[Cl:48].[F:1][c:2]1[c:3]([NH:24][c:25]2[c:26]([F:32])[cH:27][c:28]([I:31])[cH:29][cH:30]2)[c:4]([C:5](=[O:6])[NH:7][O:8][CH2:9][CH2:10][OH:11])[cH:12][c:13]([CH:16]=[N:17][O:18][CH2:19][C:20]([NH:21][CH3:22])=[O:23])[c:14]1[F:15].[OH:40][C:41]([CH:42]([Cl:43])[Cl:44])=[O:45].[n:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>>[F:1][c:2]1[c:3]([NH:24][c:25]2[c:26]([F:32])[cH:27][c:28]([I:31])[cH:29][cH:30]2)[c:4]([C:5](=[O:6])[NH:7][O:8][CH2:9][CH2:10][OH:11])[cH:12][c:13]([CH2:16][NH:17][O:18][CH2:19][C:20]([NH:21][CH3:22])=[O:23])[c:14]1[F:15]

Participants

6

Reactant 5

HCID 1049PyridineHCID 6331BoraneHCID 6344DichloromethaneHCID 6597Dichloroacetic AcidHCID 740200123,4-difluoro-2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-5-[[2-(methylamino)-2-oxoethoxy]iminomethyl]benzamide

Product 1

HCID 116210943,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(methylcarbamoylmethoxyamino-methyl)-benzamide

Sources & evidence

ORD record
ord-8e8c5af7565f48c6bc6f63afa570afe5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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