Hydrochloric Acid → HCID 86645027, compound

Participants

Reaction Conditions

Reaction Steps

Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (0.09 mL, 1.02 mmol), 3-phenoxyaniline (94 mg, 0.51 mmol) and 37% HCl solution (0.09 mL, 1.02 mmol) in 10% aqueous EtOH solution (1 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 9/1) in 75% yield (102 mg).

Provenance & Evidence