Hydrochloric Acid → HCID 86645028, compound

Participants

Reaction Conditions

Reaction Steps

Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (0.15 mL, 1.66 mmol), 3-ethoxyaniline (0.11 mL, 0.83 mmol) and 37% HCl solution (0.14 mL, 1.66 mmol) in 10% aqueous EtOH solution (1 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 8/2) in 53% yield (97 mg).

Provenance & Evidence