Hydrochloric Acid → 2-Chloro-5-(thiazol-2-ylamino)phenol

Participants

Reaction Conditions

Reaction Steps

Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (0.25 mL, 2.78 mmol), 5-amino-2-chlorophenol (200 mg, 1.39 mmol) and 37% HCl solution (0.24 mL, 2.78 mmol) in 10% aqueous EtOH solution (5 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 7/3) in 69% yield (217 mg).

Provenance & Evidence