関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Bromothiazole | HCID 76430 | — |
| 反応物 | 4-Amino-2-hydroxybenzonitrile | HCID 12468682 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Hydroxy-4-(thiazol-2-ylamino)benzonitrile | HCID 86096009 | 26% |
反応手順
Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (0.94 mL, 10.4 mmol), 4-amino-2-hydroxybenzonitrile (696 mg, 5.2 mmol) and 37% HCl solution (0.88 mL, 10.4 mmol) in 10% aqueous EtOH solution (20 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 26% yield (293 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09018209B2 |
|---|
| 出典データセット | uspto-grants-2015_04 |
|---|
| ORD ID | ord-4ca5e91211b64ea198f44c5d7bbfaee2 |
|---|
| 出典メモ | uspto-grants-2015_04 |
|---|
